New Reply Follow New Topic. Although azathioprine has been reported to be safe during pregnancy in renal transplant recipients and patients with systemic lupus erythematosus, opinions vary whether it should be continued in pregnancy in inflammatory bowel disease. 6, there was no reported increase in prematurity, spontaneous abortion, congenital anomalies, or neonatal and childhood infections in patients who were exposed to 6-MP prior to and during pregnancy … Also known as AZA, AZTP, Imuran (tn) A purine analogue with cytotoxic and immunosuppressive activity. Our findings are comparable with other studies which have similarly examined the use of AZA/6-MP in IBD women during pregnancy. Use of azathioprine and corticosteroids was often reduced or discontinued before or during early pregnancy followed by an increased use of corticosteroids later in pregnancy. Treatment with azathioprine is therefore continued during pregnancy to prevent disease relapse and/or transplant rejection. Azathioprine. Send thanks to the doctor. best sellers. home. It has been administered to many pregnant women over many years without significant side effects. A 40-year-old member asked: do you need a prescription for imuran (azathioprine)? If you become pregnant while taking this drug, call your doctor right away. 6, 13, 14 In a retrospective cohort study by Francella et al. Alstead EM, Ritchie JK, Lennard-Jones JE, et al. Ever since, I was on some medications in order to control my disease. marjy33405 over a year ago. However, there have been reports of premature birth and low birth-weight following exposure to azathioprine, particularly in combination with corticosteroids. 0. Currently, infants born to mothers taking azathioprine in pregnancy do not routinely have their haemoglobin level measured. Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: their mechanisms of action … While azathioprine is probably safe in all of these situations, you must always discuss azathioprine use with your doctor before planning a pregnancy. Azathioprine is normally converted to the active metabolite 6-mercaptopurine. Azathioprine should be used during pregnancy only if the potential benefit justifies the potential risk. 6, 9-11 Furthermore, supported by animal and human data (on renal transplant recipients only), the use of azathioprine in pregnancy may be related to intrauterine growth … Imuran ® (azathioprine) may not be safe for use in pregnant women. Whenever possible, use of azathioprine in pregnant patients … Azathioprine has been classed as FDA category D – positive evidence of risk. Imuran (azathioprine): Imuran (azathioprine) is FDA pregnancy category D (Positive evidence of risk) 2 doctors agree. 41,71 Data relating to rheumatologic diseases are limited, and although azathioprine is being used during pregnancy, it is better avoided during pregnancy and lactation if possible. In animal studies, the drug increased the risk of certain birth defects. 0 comment. This seems to have worked, but I have recently found out that I am pregnant and am concerned about the effects on the baby. The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. In addition the fetal liver does not have inosinatopyrophosphorylase which therefore largely protects the fetus from … Azathioprine should not be started de novo in pregnant women; its long latency to therapeutic effect would make this an illogical choice for immunosuppression in this setting. If the benefits of treatment with azathioprine (for instance, to maintain remission during pregnancy) outweigh the risks, this drug may be continued during pregnancy… The immunosuppressive agent azathioprine is considered a pregnancy category D drug, with some evidence of increased risk of fetal abnormalities in human studies. Do you have to come off the tablets before becoming pregnant? Has anyone experienced taking Azathioprine whilst pregnant? Overall, azathioprine concentration in breast milk is very low and mothers taking azathioprine may breast feed; any detectable concentration of azathioprine … The most important thing is that your AIH is as controlled as well as possible during pregnancy. Men are also fine to continue taking it when trying for a baby. Dr. Heidi Fowler answered. Unlike mercaptopurine,' , =, 3 a closely related analogue, azathioprine has been found to have no teratogenic activity in the rat .4 However, the present study, previously reported in part,' has demonstrated a profound effect of the drug on pregnancy in … I’m 10 weeks gone now and I did stop taking my medication but my consultant is adamant that it won’t cause the baby any harm. This is because the evidence for safety is not absolutely watertight. Is azathioprine safe in pregnancy and breastfeeding? Immunomodulators. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). The objective of this study was to evaluate the risk of adverse fetal outcome in systemic lupus erythematosus (SLE) women exposed to azathioprine during pregnancy. Azathioprine (Imuran) in Pregnancy/Lactation I have been taking this drug for 4 years to control Crohn's Disease related problems. 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6 … Current guidelines say that azathioprine can be taken if trying for a baby and even when pregnant or breastfeeding. A retrospective analysis of the outcome of 16 pregnancies in 14 women receiving azathioprine … Angrybird Moderator. azathioprine in pregnancy . Azathioprine crosses the placenta, but drug and metabolite concentrations are lower in the fetal circulation, suggesting placental metabolism. The objective of this study was to evaluate the risk of adverse fetal outcome in systemic lupus erythematosus (SLE) women exposed to azathioprine during pregnancy … I have been taking Azathioprine for nearly a year now. Before taking azathioprine. 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